⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13397644 | 0.79 | KDM4E (0.46) | — | |
| SCHEMBL10401862 | 0.79 | KDM4E (0.46) | — | |
| SCHEMBL366043 | 0.78 | — | — | |
| SCHEMBL1262877 | 0.77 | — | — | |
| SCHEMBL868382 | 0.77 | — | — | |
| SCHEMBL14302871 | 0.74 | — | — | |
| SCHEMBL11050420 | 0.74 | — | — | |
| SCHEMBL8444658 | 0.74 | — | — | |
| SCHEMBL126980 | 0.74 | — | — | |
| SCHEMBL3318462 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264494-A1 | Heterocyclic amide derivatives which process glycogen phorylase inhibitory activity | ASTRAZENECA AB (SE) | 2006-11-23 | — | — | US | disclosed |
| US-20060199966-A1 | Indol-2-amides as glycogen phosphorylase inhibitors | ASTRAZENECA AB (SE) | 2006-09-07 | — | — | US | disclosed |
| EP-1660448-A1 | INDOL-2-AMIDES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | Astrazeneca AB (SE) | 2006-05-31 | — | — | EP | disclosed |
| EP-1656136-A1 | HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005019172-A1 | INDOL-2-AMIDES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005018637-A1 | HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-03-03 | — | — | WO | disclosed |