Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 10/20 | 0.74 |
| ▸ | EGFR | P00533 | 12/20 | 0.71 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | LYN | P07948 | 1/20 | 0.69 |
| ▸ | RET | P07949 | 1/20 | 0.69 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.69 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.69 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.69 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.69 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.69 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.69 |
| ▸ | ADK | P55263 | 1/20 | 0.69 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.69 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086424 | 1.00 | ERBB2 (0.74) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3131692 | 0.95 | ERBB2 (0.79) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3127263 | 0.95 | ERBB2 (0.79) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3123531 | 0.94 | ERBB2 (0.73) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL1384917 | 0.92 | EGFR (0.81) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL6604725 | 0.92 | ERBB2 (0.70) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3127172 | 0.91 | ERBB2 (0.75) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL4877718 | 0.90 | ERBB2 (0.80) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3121700 | 0.90 | EGFR (0.84) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL12304864 | 0.90 | ERBB2 (0.75) | ERBB2EGFRGAKRIPK2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667991-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | Astrazeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005026150-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |