Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.57 |
| ▸ | AURKA | O14965 | 12/20 | 0.57 |
| ▸ | TEK | Q02763 | 12/20 | 0.57 |
| ▸ | MET | P08581 | 10/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.57 |
| ▸ | LCK | P06239 | 8/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | FGR | P09769 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 3/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2747033 | 0.86 | KDR (0.72) | KDRAURKATEKMETAURKB | |
| SCHEMBL2746830 | 0.83 | KDR (0.70) | KDRAURKATEKMETAURKB | |
| SCHEMBL2749314 | 0.83 | KDR (0.70) | KDRAURKATEKMETAURKB | |
| SCHEMBL4549070 | 0.83 | KDR (0.68) | KDRAURKATEKMETAURKB | |
| SCHEMBL5451451 | 0.80 | KDR (0.75) | KDRAURKATEKMETAURKB | |
| SCHEMBL4549051 | 0.78 | KDR (0.74) | KDRAURKATEKMETAURKB | |
| SCHEMBL4548741 | 0.77 | KDR (0.69) | KDRAURKATEKMETAURKB | |
| SCHEMBL2749249 | 0.76 | KDR (0.69) | KDRAURKATEKMETAURKB | |
| SCHEMBL2748514 | 0.76 | KDR (0.72) | KDRAURKATEKMETAURKB | |
| SCHEMBL2747074 | 0.76 | KDR (0.67) | KDRAURKATEKMETAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |