Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.50 |
| ▸ | PDE4A | P27815 | 4/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359528 | 0.90 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE1C | |
| SCHEMBL5355973 | 0.90 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE1C | |
| SCHEMBL5755235 | 0.90 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5757334 | 0.90 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5757402 | 0.88 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5362577 | 0.87 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPDE1C | |
| SCHEMBL5371305 | 0.87 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPDE1C | |
| SCHEMBL5362574 | 0.87 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPDE1C | |
| SCHEMBL5351742 | 0.86 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDE1C | |
| SCHEMBL5757437 | 0.85 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-B1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORP (US) | 2006-05-03 | — | — | EP | claimed |