Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14611607 | 1.00 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL5370207 | 1.00 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL5370202 | 1.00 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL14575984 | 1.00 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL5355688 | 0.88 | MAPK1 (0.47) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL5355540 | 0.88 | MAPK1 (0.47) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL5355685 | 0.88 | MAPK1 (0.47) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL5355537 | 0.88 | MAPK1 (0.47) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL14611654 | 0.88 | KMT2A (0.43) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL14575696 | 0.88 | KMT2A (0.43) | PDE4BPDE4APDE4CPDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-B1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORP (US) | 2006-05-03 | — | — | EP | claimed |
| US-6423710-B1 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION | 2002-07-23 | — | — | US | claimed |