Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.53 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755588 | 1.00 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DSIGMAR1 | |
| SCHEMBL5754945 | 0.97 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DSIGMAR1 | |
| SCHEMBL5755237 | 0.97 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DSIGMAR1 | |
| SCHEMBL5759358 | 0.95 | PDE4B (0.53) | PDE4BSIGMAR1 | |
| SCHEMBL5756191 | 0.95 | PDE4B (0.53) | PDE4BSIGMAR1 | |
| SCHEMBL5356884 | 0.93 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5357639 | 0.93 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL14577351 | 0.93 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7361038 | 0.93 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7697445 | 0.92 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-B1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORP (US) | 2006-05-03 | — | — | EP | claimed |