Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.56 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 7/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.56 |
| ▸ | GFER | P55789 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789060 | 0.85 | MAPT (0.45) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL5789065 | 0.85 | MAPT (0.45) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL5751505 | 0.84 | MAPT (0.48) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL5754707 | 0.84 | MAPT (0.48) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL5757076 | 0.81 | MAPT (0.48) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL5756758 | 0.81 | MAPT (0.48) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL23246023 | 0.71 | NPC1 (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL11871568 | 0.70 | MEN1 (0.56) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL28409304 | 0.69 | — | — | |
| SCHEMBL27800775 | 0.69 | MEN1 (0.54) | MEN1KMT2AMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648884-A2 | PYRAZOLYL-INDOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005005414-A2 | PYRAZOLYL-INDOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2005-01-20 | — | — | WO | disclosed |