Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 10/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3546408 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL3548172 | 0.93 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL3546489 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL3551575 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL3547789 | 0.90 | SMN1; SMN2 (0.48) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL3554548 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL5246847 | 0.89 | TP53 (0.56) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL3545839 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL3548397 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE4APDE4BTP53PDE4C | |
| SCHEMBL3547641 | 0.89 | PDE4B (0.49) | SMN1; SMN2PDE4APDE4BTP53PDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613590-A2 | 4-(3,4-DISUBSTITUTED PHENYL)-PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2006-01-11 | — | — | EP | claimed |
| WO-2004094375-A2 | 4 - (3,4 - DISUBSTITUTED PHENYL) - PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | claimed |