Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.82 |
| ▸ | FLT1 | P17948 | 10/20 | 0.82 |
| ▸ | KDR | P35968 | 10/20 | 0.82 |
| ▸ | EGFR | P00533 | 15/20 | 0.73 |
| ▸ | FLT4 | P35916 | 8/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1467367 | 0.91 | FGFR1 (1.00) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL4082342 | 0.86 | FGFR1 (0.74) | FGFR1FLT1KDREGFRFLT4 | |
| Hydrochloric Acid SCHEMBL1466890 | 0.86 | KDR (0.89) | FGFR1FLT1KDREGFRFLT4 | |
| Hydrochloric Acid SCHEMBL4086431 | 0.85 | FLT1 (0.78) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL14205559 | 0.84 | FGFR1 (0.75) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL5756521 | 0.84 | FGFR1 (0.75) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL4089188 | 0.84 | FGFR1 (0.75) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL14205853 | 0.84 | FGFR1 (0.75) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL13604789 | 0.84 | FGFR1 (0.75) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL3012896 | 0.83 | KDR (1.00) | FGFR1FLT1KDREGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667991-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | Astrazeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005026150-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |