Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760268 | 0.92 | ADORA2A (0.41) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5757120 | 0.81 | IDO1 (0.47) | PDE4BPDE4DKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL5759370 | 0.80 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5758859 | 0.77 | PDE4B (0.41) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL3602989 | 0.74 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DERN1 | |
| SCHEMBL3609807 | 0.73 | MAPT (0.42) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5755717 | 0.69 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL27293614 | 0.68 | AR (0.45) | KDM4ELMNATSHRALDH1A1HSD17B10 | |
| SCHEMBL3605628 | 0.68 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL30002764 | 0.67 | FFAR1 (0.66) | KDM4ELMNANPY1RHTTNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |