Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759835 | 0.92 | PPARG (0.44) | PPARGCACNA1HCACNA1BTDP1PPARD | |
| SCHEMBL5206804 | 0.83 | PPARG (0.68) | PPARGPPARDPPARA | |
| SCHEMBL5756704 | 0.80 | PPARG (0.66) | PPARGPPARDPPARA | |
| SCHEMBL5759781 | 0.80 | PPARG (0.61) | PPARGPPARDPPARA | |
| SCHEMBL5756584 | 0.78 | PPARG (0.63) | PPARGPPARDPPARA | |
| SCHEMBL5206181 | 0.78 | TDP1 (0.47) | PPARGCACNA1HCACNA1BTDP1PPARD | |
| SCHEMBL5760036 | 0.78 | PPARG (0.59) | PPARGPPARDPPARA | |
| SCHEMBL5758631 | 0.77 | PPARG (0.60) | PPARGPPARDPPARA | |
| SCHEMBL5758304 | 0.77 | PPARG (0.47) | PPARGPPARDPPARA | |
| SCHEMBL5204003 | 0.77 | TDP1 (0.47) | PPARGCACNA1HCACNA1BTDP1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194146-B1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2006-07-19 | — | — | EP | claimed |
| US-6399640-B1 | ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS | MERCK & CO., INC. | 2002-06-04 | — | — | US | claimed |
| EP-1194146-B1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2006-07-19 | — | — | EP | disclosed |
| EP-1194146-A4 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6399640-B1 | ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS | MERCK & CO., INC. | 2002-06-04 | — | — | US | disclosed |
| EP-1194146-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078312-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |