Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1168653 | 1.00 | CCR4 (0.39) | CCR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5758335 | 0.81 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1169189 | 0.81 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1169403 | 0.81 | CDK1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2886949 | 0.80 | PSEN1 (0.62) | CCR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1169647 | 0.76 | PSEN1 (0.64) | CCR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5758655 | 0.76 | PSEN1 (0.64) | CCR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5757470 | 0.76 | PSEN1 (0.64) | CCR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1169173 | 0.76 | PSEN1 (0.64) | CCR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1169218 | 0.75 | PSEN1 (0.41) | CCR4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-B1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2006-06-21 | — | — | EP | claimed |