Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755555 | 0.93 | GRM4 (0.55) | KMT2AGAAMEN1SMN1; SMN2NPC1 | |
| SCHEMBL5755596 | 0.88 | KMT2A (0.69) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13390691 | 0.81 | SMN1; SMN2 (0.61) | KMT2ACYP1A2CYP2C9CYP2C19GAA | |
| SCHEMBL12386255 | 0.77 | GRM4 (0.60) | KMT2AGAAMEN1SMN1; SMN2NPC1 | |
| SCHEMBL15678237 | 0.76 | KMT2A (0.54) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9817876 | 0.76 | GRM4 (0.58) | KMT2ACYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL6671177 | 0.75 | HTT (0.58) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9313903 | 0.75 | KMT2A (0.57) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8737928 | 0.75 | POLB (0.61) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL31184650 | 0.74 | GRM4 (0.61) | KMT2ACYP1A2CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487443-A4 | HETEROCYCLIC AMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES AND OTHER DISEASES | INCYTE SAN DIEGO INC (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1487443-A1 | HETEROCYCLIC AMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES AND OTHER DISEASES | Incyte San Diego Incorporated (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003075924-A1 | HETEROCYCLIC AMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES AND OTHER DISEASES | INCYTE SAN DIEGO INCORPORATED (US) | 2003-09-18 | — | — | WO | disclosed |