Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216694 | 0.95 | PDE10A (0.44) | PDE10AMAPK8KLKB1RXFP1KDM4E | |
| SCHEMBL5756461 | 0.93 | PDE10A (0.48) | PDE10AKLKB1RXFP1ELANETP53 | |
| SCHEMBL5759073 | 0.91 | TP53 (0.49) | PDE10AKLKB1RXFP1ELANETP53 | |
| SCHEMBL5759317 | 0.90 | TP53 (0.52) | PDE10ARXFP1ELANETP53LMNA | |
| SCHEMBL5759479 | 0.90 | PDE10A (0.48) | PDE10ARXFP1ELANETP53P2RX7 | |
| SCHEMBL5757018 | 0.89 | ELANE (0.53) | KDM4EELANEMAPT | |
| SCHEMBL27624377 | 0.89 | PDE10A (0.45) | PDE10AKLKB1RXFP1ELANETP53 | |
| SCHEMBL5759410 | 0.88 | PDE10A (0.48) | PDE10AKLKB1ELANETP53LMNA | |
| SCHEMBL5758260 | 0.88 | PDE10A (0.46) | PDE10AMAPK8KLKB1ELANEP2RX7 | |
| SCHEMBL5760593 | 0.88 | ELANE (0.55) | PDE10AMAPK8ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | disclosed |
| CN-1711243-A | 2-pyridone derivatives as inhibitors of neutrophil elastase | ASTRAZENECA AB (SE) | 2005-12-21 | — | — | CN | disclosed |