Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22000638 | 0.87 | CYP4F2 (0.55) | CYP4F2CYP4A11ADRB3CDK8CLK4 | |
| SCHEMBL2349901 | 0.85 | CYP4F2 (0.50) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| SCHEMBL901639 | 0.81 | CYP4F2 (0.61) | CYP4F2CYP4A11CDK8CLK4CYP4Z1 | |
| SCHEMBL11023962 | 0.80 | CYP4F2 (0.45) | CYP4F2CYP4A11ADRB3GLAP2RX3 | |
| SCHEMBL6035695 | 0.80 | APP (0.59) | SMN1; SMN2MAPTFFAR1FFAR4HPGD | |
| SCHEMBL2500529 | 0.78 | CYP4F2 (0.46) | CYP4F2CYP4A11ADRB3CDK8CLK4 | |
| SCHEMBL16972780 | 0.78 | CYP4F2 (0.62) | CYP4F2CYP4A11CYP4Z1GLAMAPT | |
| SCHEMBL3734531 | 0.78 | CYP4F2 (0.58) | CYP4F2CYP4A11CYP4Z1SMN1; SMN2PDE3B | |
| SCHEMBL11357708 | 0.77 | ADRB3 (0.47) | CYP4F2CYP4A11ADRB3PPARGGLA | |
| SCHEMBL901787 | 0.77 | CYP4F2 (0.56) | CYP4F2CYP4A11CYP4Z1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270571-B1 | Heterocyclic compounds, their production and use | TAKEDA PHARMACEUTICAL (JP) | 2006-09-06 | — | — | EP | disclosed |
| EP-1270571-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
| CN-1349990-A | Heterocyclic compound, its preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-05-22 | — | — | CN | disclosed |
| CN-1077107-C | Heterocyclic compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-02 | — | — | CN | disclosed |
| US-6211215-B1 | AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| CN-1223653-A | Heterocyclic compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |