Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 10/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 10/20 | 0.47 |
| ▸ | USP2 | O75604 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758853 | 0.90 | MAPK1 (0.53) | CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL5757558 | 0.87 | MAPK1 (0.50) | ALDH1A1HPGDKDM4EMAPK1HIF1A | |
| SCHEMBL5758071 | 0.86 | MAP4K4 (0.52) | ACHEMAPK1MAPTHIF1ATP53 | |
| SCHEMBL5760664 | 0.86 | BCHE (0.48) | BCHEACHEMAPK1MAPK14PIK3CA | |
| SCHEMBL5759694 | 0.84 | APP (0.47) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL5757877 | 0.84 | MAPK1 (0.62) | MAPK1HIF1AMAPK14PIK3CAMAPK8 | |
| SCHEMBL5760181 | 0.82 | PDE5A (0.55) | ALDH1A1SMN1; SMN2KDM4EBCHEACHE | |
| SCHEMBL5755117 | 0.81 | MAPK1 (0.51) | SMN1; SMN2MAPK1HIF1AMAPK14PIK3CA | |
| SCHEMBL5758049 | 0.80 | MAPK1 (0.48) | ALDH1A1HPGDSMN1; SMN2KDM4EACHE | |
| SCHEMBL5757913 | 0.80 | PIK3CA (0.54) | SMN1; SMN2BCHEACHEMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028729-B1 | METHODS OF MODULATING SERINE/THREONINE PROTEIN KINASE FUNCTION WITH 5-AZAQUINOXALINE-BASED COMPOUNDS | ZENTARIS GMBH (DE) | 2006-08-16 | — | — | EP | disclosed |
| US-6727252-B1 | THE SERINE/THREONINE KINASE FAMILY INCLUDES MEMBERS THAT REGULATE CELL GROWTH, MIGRATION, DIFFERENTIATION, GENE EXPRESSION, MUSCLE CONTRACTION, GLUCOSE METABOLISM, CELLULAR PROTEIN SYNTHESIS, AND REGULATION OF THE CELL CYCLE | ZENTARIS AG (DE) | 2004-04-27 | — | — | US | disclosed |
| US-6180631-B1 | PREVENTING AND TREATING SERINE/THREONINE PROTEIN KINASE-RELATED ABNORMAL CONDITIONS IN MAMMALS ASSOCIATED WITH AN ABERRATION IN A SIGNAL TRANSDUCTION PATHWAY SUCH AS CANCER OR A FIBROTIC DISORDER | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 2001-01-30 | — | — | US | disclosed |
| EP-1028729-A2 | METHODS OF MODULATING SERINE/THREONINE PROTEIN KINASE FUNCTION WITH 5-AZAQUINOXALINE-BASED COMPOUNDS | ASTA Medica Aktiengesellschaft (DE) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999017759-A2 | METHODS OF MODULATING SERINE/THREONINE PROTEIN KINASE FUNCTION WITH 5-AZAQUINOXALINE-BASED COMPOUNDS | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1999-04-15 | — | — | WO | disclosed |