Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 18/20 | 0.49 |
| ▸ | PPARA | Q07869 | 16/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759869 | 1.00 | PTPN2 (0.50) | PTPN2PTPN1PPARGPPARAPPARD | |
| SCHEMBL5760311 | 0.93 | PTPN2 (0.51) | PTPN2PTPN1PPARGPPARAPPARD | |
| SCHEMBL5760314 | 0.93 | PTPN2 (0.51) | PTPN2PTPN1PPARGPPARAPPARD | |
| SCHEMBL5761602 | 0.86 | PPARG (0.51) | PTPN2PTPN1PPARGPPARAPPARD | |
| SCHEMBL5759620 | 0.85 | PPARG (0.48) | PTPN2PTPN1PPARGPPARAPPARD | |
| SCHEMBL5762732 | 0.82 | PPARG (0.48) | PTPN2PTPN1PPARGPPARAPPARD | |
| SCHEMBL5760923 | 0.81 | NPC1 (0.54) | PTPN2PTPN1PPARGPPARAPPARD | |
| SCHEMBL5762399 | 0.80 | PTPN2 (0.60) | PTPN2PTPN1PPARGPPARA | |
| SCHEMBL5762401 | 0.80 | PTPN2 (0.60) | PTPN2PTPN1PPARGPPARA | |
| SCHEMBL5760205 | 0.80 | PPARG (0.51) | PTPN2PTPN1PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392295-B1 | CARBOXYLIC ACID SUBSTITUTED OXAZOLE DERIVATIVES FOR USE AS PPAR-ALPHA AND -GAMMA ACTIVATORS IN THE TREATMENT OF DIABETES | HOFFMANN LA ROCHE (CH) | 2006-05-31 | — | — | EP | disclosed |
| EP-1392295-A1 | CARBOXYLIC ACID SUBSTITUTED OXAZOLE DERIVATIVES FOR USE AS PPAR-ALPHA AND -GAMMA ACTIVATORS IN THE TREATMENT OF DIABETES | F. Hoffmann-La Roche AG (CH) | 2004-03-03 | — | — | EP | disclosed |
| US-6642389-B2 | For therapy of diabetes | HOFFMANN-LA ROCHE INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030055265-A1 | Oxazole derivatives | HOFFMANN-LA ROCHE INC. | 2003-03-20 | — | — | US | disclosed |
| WO-2002092084-A1 | CARBOXYLIC ACID SUBSTITUTED OXAZOLE DERIVATIVES FOR USE AS PPAR-ALPHA AND -GAMMA ACTIVATORS IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055265-A1 | Oxazole derivatives | PPARD, PPARA, PPARG | PTPN2 1544/4885PTPN1 1613/4885PPARG 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.