Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503490 | 0.91 | KDM4E (0.40) | TSHRSMN1; SMN2KDM4EMCHR1CHRM2 | |
| SCHEMBL4877080 | 0.81 | KDM4E (0.45) | TSHRSMN1; SMN2KDM4ECHRM2CHRM5 | |
| SCHEMBL25208208 | 0.81 | PARP1 (0.43) | EPHX2SMN1; SMN2KDM4EMCHR1CHRM2 | |
| SCHEMBL23152417 | 0.81 | PARP1 (0.43) | EPHX2SMN1; SMN2KDM4EMCHR1CHRM2 | |
| SCHEMBL4117382 | 0.81 | PARP1 (0.43) | EPHX2SMN1; SMN2KDM4EMCHR1CHRM2 | |
| SCHEMBL31580602 | 0.80 | DPP7 (0.37) | KDM4EMCHR1SMYD3 | |
| SCHEMBL3833559 | 0.76 | EPHX2 (0.39) | EPHX2CYP3A4KDM4ECHRM2CHRM5 | |
| SCHEMBL3827038 | 0.76 | EPHX2 (0.39) | EPHX2CYP3A4KDM4ECHRM2CHRM5 | |
| SCHEMBL18115895 | 0.76 | EPHX2 (0.39) | EPHX2CYP3A4KDM4ECHRM2CHRM5 | |
| SCHEMBL5996911 | 0.75 | TSHR (0.55) | TSHREPHX2SMN1; SMN2CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000811-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |