Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 20/20 | 0.64 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887579 | 0.93 | DRD4 (0.67) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL5666675 | 0.85 | DRD4 (0.63) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL4315640 | 0.83 | DRD4 (0.72) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL13887694 | 0.83 | DRD4 (0.72) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL7366679 | 0.82 | DRD4 (0.63) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL7366712 | 0.81 | DRD4 (0.72) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL11973909 | 0.80 | DRD4 (0.76) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL7371617 | 0.80 | DRD4 (0.76) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL4312139 | 0.80 | DRD4 (0.60) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL4310365 | 0.80 | DRD4 (0.63) | DRD4DRD2DRD3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682523-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047272-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-05-26 | — | — | WO | disclosed |