Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.45 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764247 | 0.87 | DRD4 (0.41) | DRD4CYP2A13CNR2CYP1A2CYP3A4 | |
| SCHEMBL2913233 | 0.83 | DRD4 (0.45) | DRD4CYP2A13GAALMNANPC1 | |
| SCHEMBL5046461 | 0.79 | DRD4 (0.47) | DRD4CYP2A13LMNANPC1RAB9A | |
| SCHEMBL8284139 | 0.79 | DRD4 (0.47) | DRD4CYP2A13LMNANPC1RAB9A | |
| SCHEMBL14203061 | 0.79 | DRD4 (0.47) | DRD4CYP2A13LMNANPC1RAB9A | |
| SCHEMBL5762202 | 0.79 | DRD4 (0.46) | DRD4SIGMAR1 | |
| SCHEMBL8293438 | 0.75 | DRD4 (0.45) | DRD4CYP2A13CNR2CYP1A2CYP3A4 | |
| SCHEMBL5667120 | 0.75 | CNR2 (0.43) | DRD4CNR2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14580282 | 0.73 | SLC6A2 (0.46) | DRD4CYP2A13CNR2CYP1A2CYP3A4 | |
| SCHEMBL5044506 | 0.73 | SLC6A2 (0.46) | DRD4CYP2A13CNR2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682523-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005047272-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-05-26 | — | — | WO | disclosed |