Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.55 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2102310 | 0.94 | EGFR (0.69) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL2099770 | 0.93 | EGFR (0.83) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL5765979 | 0.93 | EGFR (0.70) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL2103109 | 0.92 | EGFR (0.69) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL2098676 | 0.92 | EGFR (0.69) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL5763018 | 0.90 | EGFR (0.72) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL2102233 | 0.90 | EGFR (0.87) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL5766082 | 0.89 | EGFR (0.70) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL4010712 | 0.87 | EGFR (0.62) | EGFRERBB2MEN1KMT2AMAPK1 | |
| SCHEMBL4004477 | 0.87 | EGFR (0.74) | EGFRERBB2MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460072-B1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LTD (GB) | 2006-04-05 | — | — | EP | claimed |
| EP-1460072-A1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2004-09-22 | — | — | EP | claimed |
| EP-1460072-B1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LTD (GB) | 2006-04-05 | — | — | EP | disclosed |
| EP-1460072-A1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2004-09-22 | — | — | EP | disclosed |