SCHEMBL5763178

SCHEMBL5763178

CCCN(Cc1ccc(Cl)c(Cl)c1)[C@H]1CCNC1

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 17/20 0.59
SLC6A4 P31645 17/20 0.59
SLC6A3 Q01959 12/20 0.59
KCNH2 Q12809 3/20 0.54
CYP2D6 P10635 3/20 0.54
CYP1A2 P05177 2/20 0.54
CYP3A4 P08684 2/20 0.54
CYP2C9 P11712 2/20 0.54
CYP2C19 P33261 2/20 0.54
NOS3 P29474 1/20 0.47
NOS1 P29475 1/20 0.47
NOS2 P35228 1/20 0.47
SIGMAR1 Q99720 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4486367 0.93 SLC6A2 (0.69) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL5761184 0.85 SLC6A2 (0.56) SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4
SCHEMBL5995618 0.85 SLC6A2 (0.59) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL4483656 0.84 SLC6A2 (0.69) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL5762010 0.84 SLC6A2 (0.58) SLC6A2SLC6A4SLC6A3CYP2D6NOS3
SCHEMBL4497251 0.83 SLC6A2 (0.67) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL4491890 0.83 SLC6A2 (0.53) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL16163219 0.81 SLC6A4 (0.65) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL4485346 0.80 SLC6A2 (0.70) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL26387507 0.80 SLC6A2 (0.62) SLC6A2SLC6A4SLC6A3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1638934-A1 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE ELI LILLY AND COMPANY (US) 2006-03-29 EP claimed
WO-2005000811-A1 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE ELI LILLY AND COMPANY (US) 2005-01-06 WO claimed
EP-1638934-A1 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE ELI LILLY AND COMPANY (US) 2006-03-29 EP disclosed
WO-2005000811-A1 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE ELI LILLY AND COMPANY (US) 2005-01-06 WO disclosed