Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 17/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 16/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762868 | 0.85 | SLC6A2 (0.64) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4495136 | 0.83 | SLC6A4 (0.46) | SLC6A4SLC6A2SLC6A3CYP2D6GAA | |
| SCHEMBL5819349 | 0.81 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3CYP2D6NOS3 | |
| SCHEMBL4494130 | 0.81 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3CYP2D6MBTPS1 | |
| SCHEMBL5996334 | 0.80 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3GAA | |
| SCHEMBL4498629 | 0.80 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3CYP2D6GAA | |
| SCHEMBL4489224 | 0.79 | SLC6A2 (0.70) | SLC6A4SLC6A2SLC6A3CYP2D6GAA | |
| SCHEMBL4479065 | 0.78 | SLC6A4 (0.53) | SLC6A4SLC6A2SLC6A3CYP2D6GAA | |
| SCHEMBL4482954 | 0.78 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3CYP2D6MBTPS1 | |
| SCHEMBL5994714 | 0.77 | SLC6A2 (0.73) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2005000811-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | claimed |