Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.70 |
| ▸ | EGFR | P00533 | 5/20 | 0.70 |
| ▸ | SRC | P12931 | 2/20 | 0.70 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.70 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.70 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.70 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.51 |
| ▸ | SIK1 | P57059 | 1/20 | 0.50 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.50 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5761151 | 0.93 | FGFR1 (0.73) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5763110 | 0.89 | FGFR1 (0.72) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764179 | 0.89 | FGFR1 (0.66) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5762809 | 0.86 | FGFR1 (0.63) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764765 | 0.85 | FGFR1 (0.67) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764386 | 0.83 | FGFR1 (0.68) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764483 | 0.83 | FGFR1 (0.67) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL4839269 | 0.83 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5762794 | 0.82 | FGFR1 (0.66) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5761985 | 0.82 | FGFR1 (0.66) | FGFR1EGFRSRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | claimed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | claimed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | claimed |
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | disclosed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | disclosed |