Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MC4R | P32245 | 11/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4360145 | 0.91 | KDM4E (0.65) | KDM4ETDP1MC4RCCR5MEN1 | |
| SCHEMBL4816169 | 0.88 | MC4R (0.45) | MC4RCCR5 | |
| SCHEMBL4369281 | 0.82 | KDM4E (0.51) | KDM4ETDP1MC4RALDH1A1KMT2A | |
| SCHEMBL4359119 | 0.81 | KDM4E (0.50) | KDM4ETDP1MC4RALDH1A1 | |
| SCHEMBL4006591 | 0.81 | KDM4E (0.65) | KDM4ETDP1MC4RCCR5ALDH1A1 | |
| SCHEMBL4007682 | 0.76 | KCNH2 (0.54) | MC4RCCR5 | |
| SCHEMBL4008856 | 0.75 | KDM4E (0.66) | KDM4ETDP1MC4RCCR5ALDH1A1 | |
| SCHEMBL4006364 | 0.75 | KDM4E (0.66) | KDM4ETDP1MC4RCCR5MEN1 | |
| SCHEMBL4147186 | 0.72 | MC4R (0.54) | KDM4ETDP1MC4R | |
| SCHEMBL4006667 | 0.71 | KCNH2 (0.56) | MC4RCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644337-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Gene Logic, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005121100-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | GENE LOGIC INC. (US) | 2005-12-22 | — | — | WO | disclosed |