SCHEMBL5763591

SCHEMBL5763591

Cc1cccc(C)c1-c1cc2cnc(N)nc2n(C)c1=O

nearest known ligand 0.77

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SRC P12931 6/20 0.77
FGFR1 P11362 5/20 0.77
FGFR2 P21802 2/20 0.77
FGFR4 P22455 2/20 0.77
FGFR3 P22607 2/20 0.77
EGFR P00533 2/20 0.77
WEE1 P30291 5/20 0.65
ABL1 P00519 2/20 0.52
PDGFRB P09619 2/20 0.52
PDGFRA P16234 2/20 0.52
MAPK14 Q16539 2/20 0.52
KIT P10721 1/20 0.52
BRAF P15056 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5762370 0.88 FGFR1 (0.64) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL4839269 0.87 FGFR1 (1.00) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL5760862 0.84 FGFR1 (0.55) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL2245255 0.82 FGFR1 (0.67) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL4423133 0.82 SRC (0.66) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL26930657 0.79 BRAF (0.64) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL31338489 0.79 BRAF (0.64) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL16426416 0.78 SIK2 (0.61) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL5057413 0.77 SRC (0.54) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL24224923 0.76 FGFR1 (0.65) SRCFGFR1FGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0823908-B1 PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER LAMBERT CO (US) 2006-11-02 EP claimed
WO-2005105097-A2 PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES GPC BIOTECH AG (DE) 2005-11-10 WO claimed
EP-0823908-A1 PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1998-02-18 EP claimed
US-5620981-A ANTICARCINOGENIC AGENTS, ATHEROSCLEROSIS, RESTENOSIS, PSORIASIS WARNER-LAMBERT COMPANY (US) 1997-04-15 US claimed
WO-1996034867-A1 PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1996-11-07 WO claimed
EP-0823908-B1 PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER LAMBERT CO (US) 2006-11-02 EP disclosed
WO-2005105097-A2 PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES GPC BIOTECH AG (DE) 2005-11-10 WO disclosed
US-5945422-A ANTICANCER AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS WARNER-LAMBERT COMPANY (US) 1999-08-31 US disclosed
US-5733914-A Pyrido 2, 3-d!pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation WARNER-LAMBERT COMPANY (US) 1998-03-31 US disclosed
EP-0823908-A1 PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1998-02-18 EP disclosed
US-5620981-A ANTICARCINOGENIC AGENTS, ATHEROSCLEROSIS, RESTENOSIS, PSORIASIS WARNER-LAMBERT COMPANY (US) 1997-04-15 US disclosed
WO-1996034867-A1 PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1996-11-07 WO disclosed