Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.63 |
| ▸ | EGFR | P00533 | 4/20 | 0.63 |
| ▸ | WEE1 | P30291 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20563456 | 0.88 | FGFR1 (0.55) | FGFR1EGFRWEE1RIPK2ACVR1 | |
| SCHEMBL20563997 | 0.88 | RIPK2 (0.53) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL29498192 | 0.88 | RIPK2 (0.53) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL29498223 | 0.88 | FGFR1 (0.55) | FGFR1EGFRWEE1RIPK2ACVR1 | |
| SCHEMBL20563454 | 0.86 | RIPK2 (0.60) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL20563987 | 0.86 | RIPK2 (0.56) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL29498241 | 0.86 | RIPK2 (0.56) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL3762584 | 0.85 | FGFR1 (0.69) | FGFR1EGFRWEE1RIPK2ACVR1 | |
| SCHEMBL29498171 | 0.85 | FGFR1 (0.69) | FGFR1EGFRWEE1RIPK2ACVR1 | |
| SCHEMBL20563981 | 0.85 | RIPK2 (0.61) | FGFR1EGFRRIPK2ACVR1NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | claimed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | claimed |
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | disclosed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | disclosed |