Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 20/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484578 | 0.83 | SLC6A4 (0.55) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4487638 | 0.81 | SLC6A2 (0.76) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4486645 | 0.81 | SLC6A2 (0.67) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4489175 | 0.81 | SLC6A2 (0.67) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5997083 | 0.80 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4497261 | 0.80 | SLC6A2 (0.87) | SLC6A2SLC6A4SLC6A3 | |
| Cadaverine Tartrate SCHEMBL4489954 | 0.80 | SLC6A4 (0.66) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4486481 | 0.78 | SLC6A2 (0.86) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4488128 | 0.77 | SLC6A2 (0.84) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4477264 | 0.77 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000811-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |