Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.68 |
| ▸ | EGFR | P00533 | 4/20 | 0.68 |
| ▸ | WEE1 | P30291 | 10/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCND2 | P30279 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762216 | 0.89 | FGFR1 (0.87) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5763564 | 0.82 | FGFR1 (0.60) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5762083 | 0.81 | FGFR1 (1.00) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5764292 | 0.80 | FGFR1 (0.58) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5762627 | 0.78 | FGFR1 (0.56) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5764601 | 0.78 | FGFR1 (0.56) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5764948 | 0.77 | CDK4 (0.56) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5763734 | 0.77 | FGFR1 (0.54) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764713 | 0.76 | FGFR1 (0.53) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5763753 | 0.74 | FGFR1 (1.00) | FGFR1EGFRWEE1SRCFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | disclosed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | disclosed |