Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cilansetron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3B known ✓ | O95264 | 1/20 | 0.60 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.60 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.60 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.60 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.60 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cilansetron SCHEMBL3157229 | 1.00 | CYP3A4 (0.60) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Cilansetron SCHEMBL7433386 | 1.00 | CYP3A4 (0.60) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Cilansetron SCHEMBL29883205 | 1.00 | CYP3A4 (0.60) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Cilansetron SCHEMBL3452925 | 0.99 | CYP3A4 (0.59) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Cilansetron SCHEMBL7427797 | 0.99 | CYP3A4 (0.61) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Cilansetron SCHEMBL29883543 | 0.99 | CYP3A4 (0.61) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Cilansetron SCHEMBL678512 | 0.99 | CYP3A4 (0.61) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Cilansetron SCHEMBL15950 | 0.99 | CYP3A4 (0.61) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Cilansetron SCHEMBL29019018 | 0.98 | CYP3A4 (0.60) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL21043399 | 0.87 | CYP3A4 (0.47) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565445-B1 | PROCESS FOR THE PREPARATION OF IMIDAZOLYL COMPOUNDS | SOLVAY PHARM BV (NL) | 2006-09-27 | — | — | EP | disclosed |
| US-7015333-B2 | Process for preparation of imidazolyl compounds | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-03-21 | — | — | US | disclosed |
| EP-1565445-A1 | NOVEL PROCESS FOR THE PREPARATION OF IMIDAZOLYL COMPOUNDS | Solvay Pharmaceuticals B.V. (NL) | 2005-08-24 | — | — | EP | disclosed |
| US-20040158077-A1 | Process for preparation of imidazolyl compounds | SOLVAY PHARMACEUTICALS B.V. (NL) | 2004-08-12 | — | — | US | disclosed |
| WO-2004046116-A1 | NOVEL PROCESS FOR THE PREPARATION OF IMIDAZOLYL COMPOUNDS | SOLVAY PHARMACEUTICALS B.V. (NL) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040158077-A1 | Process for preparation of imidazolyl compounds | CYP3A4, CYP4B1, CYP2C19 | HTR3B 1991/4885HTR3A 2338/4885CYP3A4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.