Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGAV | P06756 | 3/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643379 | 0.92 | ELANE (0.40) | ELANENPC1L1LMNAITGB1ITGA5 | |
| SCHEMBL5765731 | 0.92 | ELANE (0.40) | ELANENPC1L1LMNAITGB1ITGA5 | |
| SCHEMBL9587450 | 0.87 | ELANE (0.44) | ELANENPC1L1LMNAITGB1ITGA5 | |
| SCHEMBL10512340 | 0.87 | ELANE (0.44) | ELANENPC1L1LMNAITGB1ITGA5 | |
| SCHEMBL12658835 | 0.85 | ELANE (0.43) | ELANENPC1L1LMNAITGB1ITGA5 | |
| SCHEMBL5941126 | 0.83 | ELANE (0.44) | ELANENPC1L1LMNAITGB1ITGA5 | |
| SCHEMBL5764192 | 0.83 | ELANE (0.44) | ELANENPC1L1LMNAITGB1ITGA5 | |
| SCHEMBL9384838 | 0.79 | ABCB1 (0.40) | ELANEITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL7347260 | 0.79 | ELANE (0.45) | ELANELMNACA1CA2MCL1 | |
| SCHEMBL9075147 | 0.79 | ELANE (0.45) | ELANELMNACA1CA2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377577-B1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO CO (JP) | 2006-06-14 | — | — | EP | disclosed |