Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764555 | 0.89 | MAPK11 (0.41) | MAPK11MAPK14LRRK2GRM5CDC7 | |
| SCHEMBL5762860 | 0.88 | MAPK11 (0.56) | MAPK11MAPK14LRRK2CDC7ROCK2 | |
| SCHEMBL6396970 | 0.81 | MAPK11 (0.39) | MAPK11MAPK14LRRK2GRM5DCTPP1 | |
| SCHEMBL6391898 | 0.79 | MAPK11 (0.36) | MAPK11MAPK14LRRK2GRM5PIM1 | |
| SCHEMBL6391525 | 0.78 | MAPK14 (0.49) | MAPK11MAPK14GRM5PIM1 | |
| SCHEMBL5765383 | 0.78 | MAPK11 (0.57) | MAPK11MAPK14LRRK2CDC7ROCK2 | |
| SCHEMBL5764807 | 0.77 | MAPK11 (0.56) | MAPK11MAPK14LRRK2CDC7ROCK2 | |
| SCHEMBL5764488 | 0.77 | MAPK14 (0.49) | MAPK11MAPK14NPC1RAB9A | |
| SCHEMBL5763943 | 0.77 | MAPK11 (0.54) | MAPK11MAPK14LRRK2CDC7ROCK2 | |
| SCHEMBL5762518 | 0.76 | MAPK14 (0.71) | MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377577-B1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO CO (JP) | 2006-06-14 | — | — | EP | claimed |