SCHEMBL5765047

SCHEMBL5765047

COCCN(C)C(=O)c1cc(C)c2ncc(C(N)=O)c(Nc3ccc(F)c(OC)c3)c2c1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 5/20 0.64
CSF1R P07333 15/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5766207 0.90 PDE4B (0.68) PDE4BCSF1R
SCHEMBL4262341 0.83 PDE4B (0.69) PDE4BCSF1R
SCHEMBL12115499 0.82 PDE4B (0.78) PDE4BCSF1R
SCHEMBL8311769 0.79 PDE4B (0.76) PDE4BCSF1R
SCHEMBL5404672 0.78 PDE4B (0.65) PDE4BCSF1R
SCHEMBL1275852 0.78 PDE4B (1.00) PDE4BCSF1R
SCHEMBL5399192 0.78 PDE4B (0.64) PDE4BCSF1R
SCHEMBL2479970 0.77 PDE4B (0.66) PDE4BCSF1R
Formic Acid SCHEMBL2521951 0.77 PDE4B (0.72) PDE4BCSF1R
SCHEMBL1275378 0.77 PDE4B (0.74) PDE4BCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673345-A1 DERIVATIVES OF 3-AMINOCARBONYLQUINOLINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION GLAXO GROUP LIMITED (GB) 2006-06-28 EP disclosed
WO-2005030725-A1 DERIVATIVES OF 3-AMINOCARBONYLQUINOLINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION GLAXO GROUP LIMITED (GB) 2005-04-07 WO disclosed