SCHEMBL5765074

SCHEMBL5765074

CC(C)c1nnc2ccc(Sc3ccc(F)cc3)cn12

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 20/20 0.72
MAPK13 O15264 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4823102 0.87 MAPK14 (0.59) MAPK14
SCHEMBL5767610 0.85 MAPK14 (0.70) MAPK14
SCHEMBL5763350 0.85 MAPK14 (0.68) MAPK14MAPK13
SCHEMBL13745251 0.84 MAPK14 (1.00) MAPK14MAPK13
Hydrochloric Acid SCHEMBL4217990 0.83 MAPK14 (1.00) MAPK14MAPK13
SCHEMBL1283529 0.82 MAPK14 (0.60) MAPK14
SCHEMBL5765247 0.81 MAPK14 (0.73) MAPK14MAPK13
SCHEMBL13745178 0.80 MAPK14 (0.75) MAPK14MAPK13
Hydrochloric Acid SCHEMBL4215442 0.79 MAPK14 (0.76) MAPK14MAPK13
SCHEMBL5765908 0.79 MAPK14 (0.73) MAPK14MAPK13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7321040-B2 Triazolo-pyridines as anti-inflammatory compounds PFIZER INC. (US) 2008-01-22 US disclosed
US-7321040-B2 Triazolo-pyridines as anti-inflammatory compounds PFIZER INC. (US) 2008-01-22 US disclosed
EP-1601672-B1 TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS PFIZER PROD INC (US) 2006-07-26 EP disclosed