Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.43 |
| ▸ | ABL1 | P00519 | 5/20 | 0.43 |
| ▸ | INSR | P06213 | 5/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.43 |
| ▸ | PLK1 | P53350 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6891932 | 0.93 | EGFR (0.42) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3321324 | 0.93 | EGFR (0.40) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3320767 | 0.90 | EGFR (0.49) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3323064 | 0.89 | EGFR (0.45) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL4718954 | 0.85 | EGFR (0.54) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL6891928 | 0.83 | EGFR (0.37) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3320684 | 0.83 | EGFR (0.35) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3323274 | 0.81 | EGFR (0.42) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL4717859 | 0.79 | EGFR (0.54) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL4009043 | 0.77 | EGFR (0.63) | EGFRERBB2ABL1INSRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460072-B1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LTD (GB) | 2006-04-05 | — | — | EP | disclosed |
| EP-1460072-A1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2004-09-22 | — | — | EP | disclosed |