Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 4/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765672 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APREPPSEN1 | |
| SCHEMBL11174846 | 0.88 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9APREPPSEN1 | |
| SCHEMBL202453 | 0.87 | NPSR1 (0.48) | SMN1; SMN2NPC1RAB9APREPNPSR1 | |
| SCHEMBL202452 | 0.87 | NPSR1 (0.48) | SMN1; SMN2NPC1RAB9APREPNPSR1 | |
| SCHEMBL25344606 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9APREPPSEN1 | |
| SCHEMBL636520 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9APREPPSEN1 | |
| SCHEMBL4847560 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9APREPPSEN1 | |
| SCHEMBL12608462 | 0.84 | HTR2C (0.44) | SMN1; SMN2NPC1RAB9APREPPSEN1 | |
| SCHEMBL6184485 | 0.84 | PREP (0.41) | SMN1; SMN2NPC1RAB9APREPPSEN1 | |
| SCHEMBL14496579 | 0.84 | HTR2C (0.44) | SMN1; SMN2NPC1RAB9APREPPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2883876-A1 | Stereoselective synthesis of substituted pyrrolidines | Actelion Pharmaceuticals Ltd. (CH) | 2015-06-17 | — | — | EP | disclosed |
| US-7265105-B2 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2007-09-04 | — | — | US | disclosed |
| EP-1377577-B1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO CO (JP) | 2006-06-14 | — | — | EP | disclosed |
| EP-0918768-B1 | AROMATIC AMIDINE DERIVATIVES USEFUL AS SELECTIVE THROMBIN INHIBITORS | C & C RES LAB (KR) | 2002-01-09 | — | — | EP | disclosed |
| US-6201006-B1 | ANTICOAGULANTS | C & C RESEARCH LABORATORIES (KR) | 2001-03-13 | — | — | US | disclosed |
| US-4377701-A | 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid | E. R. SQUIBB & SONS, INC. (US) | 1983-03-22 | — | — | US | disclosed |