Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.62 |
| ▸ | SRC | P12931 | 4/20 | 0.62 |
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.62 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.62 |
| ▸ | PAK1 | Q13153 | 5/20 | 0.60 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.60 |
| ▸ | PAK4 | O96013 | 3/20 | 0.60 |
| ▸ | SIK2 | Q9H0K1 | 3/20 | 0.56 |
| ▸ | SIK1 | P57059 | 1/20 | 0.56 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.56 |
| ▸ | WEE1 | P30291 | 1/20 | 0.53 |
| ▸ | PAK2 | Q13177 | 4/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | STK26 | Q9P289 | 2/20 | 0.48 |
| ▸ | STK24 | Q9Y6E0 | 2/20 | 0.48 |
| ▸ | STK4 | Q13043 | 1/20 | 0.48 |
| ▸ | STK3 | Q13188 | 1/20 | 0.48 |
| ▸ | PAK3 | O75914 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764398 | 0.87 | FGFR1 (0.82) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL5762258 | 0.77 | FGFR1 (1.00) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL15580670 | 0.76 | PAK1 (0.64) | FGFR1EGFRPAK1PKN1PAK4 | |
| SCHEMBL5764642 | 0.74 | FGFR1 (1.00) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL16195710 | 0.74 | PKN1 (0.62) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL5763017 | 0.74 | FGFR1 (1.00) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL15036161 | 0.72 | PAK1 (0.73) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL15281586 | 0.72 | PAK1 (0.72) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL29593396 | 0.71 | MAPK8 (0.74) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL14014812 | 0.71 | MAPK8 (0.75) | FGFR1SRCEGFRFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |