Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.67 |
| ▸ | KDR | P35968 | 12/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.67 |
| ▸ | AURKA | O14965 | 7/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 6/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.53 |
| ▸ | FLT4 | P35916 | 3/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766436 | 0.89 | EGFR (0.59) | EGFRKDRAURKBAURKACLK1 | |
| SCHEMBL5769062 | 0.89 | EGFR (0.59) | EGFRKDRAURKBAURKACLK1 | |
| SCHEMBL5746288 | 0.88 | EGFR (0.73) | EGFRKDRAURKBAURKATEK | |
| SCHEMBL5746241 | 0.82 | ERBB2 (0.60) | EGFRKDRAURKBAURKACLK1 | |
| SCHEMBL5260398 | 0.80 | EGFR (1.00) | EGFRKDRAURKBAURKATEK | |
| SCHEMBL5746255 | 0.80 | KDR (0.56) | EGFRKDRAURKBAURKACLK1 | |
| SCHEMBL5258198 | 0.80 | EGFR (1.00) | EGFRKDRAURKBAURKACLK1 | |
| SCHEMBL5260414 | 0.79 | EGFR (0.88) | EGFRKDRAURKBAURKAABCG2 | |
| SCHEMBL2189831 | 0.77 | AURKB (0.71) | EGFRKDRAURKBAURKA | |
| SCHEMBL3954129 | 0.77 | KDR (0.72) | EGFRKDRAURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1674466-A1 | 2,5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors | 4SC AG (DE) | 2006-06-28 | — | — | EP | disclosed |