Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | APRT | P07741 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FECH | P22830 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765217 | 0.87 | RET (0.40) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5764531 | 0.86 | RET (0.37) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5766224 | 0.85 | IRAK4 (0.51) | AKT1GAKRIPK2ULK1STK10 | |
| SCHEMBL5763022 | 0.84 | NTRK1 (0.42) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5767426 | 0.83 | IRAK4 (0.42) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5766518 | 0.83 | IRAK4 (0.42) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5764066 | 0.83 | IRAK4 (0.42) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5765132 | 0.82 | MAP3K11 (0.41) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5765674 | 0.82 | IRAK4 (0.40) | GAKRIPK2ULK1STK10PRKD3 | |
| SCHEMBL5767092 | 0.82 | IRAK4 (0.40) | GAKRIPK2ULK1STK10PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019147-B1 | Benzimidazole derivatives useful as antiproliferative agents | PFIZER INC. (US) | 2006-03-28 | — | — | US | claimed |
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | claimed |
| EP-1235825-A1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | Pfizer Products Inc. (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2001040217-A1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | claimed |
| US-7019147-B1 | Benzimidazole derivatives useful as antiproliferative agents | PFIZER INC. (US) | 2006-03-28 | — | — | US | disclosed |
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1235825-A1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | Pfizer Products Inc. (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001040217-A1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |