Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260984 | 0.82 | KDM4E (0.52) | NPC1RAB9APRMT5WDR77HPGD | |
| SCHEMBL24349175 | 0.80 | PRMT5 (0.45) | KDRFGFR3NPC1RAB9APRMT5 | |
| SCHEMBL2265948 | 0.79 | PRMT5 (0.42) | NPC1RAB9APRMT5WDR77HPGD | |
| SCHEMBL2267420 | 0.79 | PRMT5 (0.43) | KDRFGFR3PRMT5WDR77GGPS1 | |
| SCHEMBL2260901 | 0.78 | POLB (0.56) | NPC1RAB9APRMT5WDR77ALDH1A1 | |
| SCHEMBL633944 | 0.77 | GGPS1 (0.57) | NPC1RAB9AHPGDGGPS1FDPS | |
| SCHEMBL14748149 | 0.76 | KDR (0.43) | KDRFGFR3NPC1RAB9APRMT5 | |
| SCHEMBL21577725 | 0.76 | KDM4E (0.35) | GGPS1FDPSKDM4EGLA | |
| SCHEMBL21941682 | 0.76 | USP7 (0.34) | KDRGGPS1FDPSKDM4EALDH1A1 | |
| SCHEMBL23651853 | 0.75 | SMN1; SMN2 (0.37) | KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483265-B1 | PURINE DERIVATIVES AS KINASE INHIBITORS | LILLY CO ELI (US) | 2006-11-22 | — | — | EP | disclosed |