Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 8/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 12/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 12/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14668105 | 0.89 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL4407178 | 0.89 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL5769693 | 0.79 | CHRNB4 (0.82) | CHRNB4CHRNA3CHRNB2CHRNA4TSHR | |
| SCHEMBL29761229 | 0.78 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNB2CHRNA4CYP3A4 | |
| SCHEMBL14668759 | 0.78 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNB2CHRNA4CYP3A4 | |
| SCHEMBL4712350 | 0.78 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNB2CHRNA4CYP3A4 | |
| Hydrochloric Acid SCHEMBL6392984 | 0.78 | CHRNB4 (0.82) | CHRNB4CHRNA3CHRNB2CHRNA4TSHR | |
| SCHEMBL14364782 | 0.74 | CHRNB4 (0.41) | CHRNB4CHRNA3CYP3A4TSHRLMNA | |
| SCHEMBL14003853 | 0.74 | CHRNB4 (0.41) | CHRNB4CHRNA3CYP3A4TSHRLMNA | |
| SCHEMBL227751 | 0.70 | SLC6A2 (0.47) | CHRNB2CHRNA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648872-A2 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | Pfizer Products Inc. (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005007630-A2 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-01-27 | — | — | WO | claimed |
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | PFIZER INC | 2005-01-27 | — | — | US | claimed |
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | PFIZER INC | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | GRIN2C, GRIN2A, GRIN2B | CHRNB4 356/4885CHRNA3 152/4885CHRNB2 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.