Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 3/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101735 | 0.93 | MAPT (0.55) | MAPTKDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL5767183 | 0.92 | KMT2A (0.46) | MAPTKMT2AMEN1APAF1ALDH1A1 | |
| SCHEMBL6101670 | 0.84 | KDM4E (0.42) | MAPTKDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL6102479 | 0.83 | PARP1 (0.41) | MAPTKDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL5766292 | 0.81 | CA12 (0.41) | KDM4EKMT2AMEN1ALDH1A1ALOX15 | |
| SCHEMBL6101386 | 0.79 | KMT2A (0.43) | MAPTKDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL5767355 | 0.78 | KDM4E (0.43) | MAPTKDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL5767865 | 0.78 | KCNN4 (0.46) | MAPTKDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL6098180 | 0.78 | UBE2N (0.45) | MAPTKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL5795396 | 0.78 | KDM4E (0.38) | MAPTKDM4EMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625130-A2 | HIV INTEGRASE INHIBITORS | Tibotec Pharmaceuticals Ltd. (IE) | 2006-02-15 | — | — | EP | claimed |
| WO-2004096807-A2 | HIV INTEGRASE INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2004-11-11 | — | — | WO | claimed |