Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772579 | 0.89 | MAPK14 (0.69) | MAPK14CYP3A4MAPK13MAPK12MAPK11 | |
| SCHEMBL5772081 | 0.85 | MAPK14 (0.61) | MAPK14CYP3A4EGFR | |
| SCHEMBL5771109 | 0.84 | MAPK14 (0.64) | MAPK14CYP3A4EGFR | |
| SCHEMBL5769521 | 0.83 | MAPK14 (0.64) | MAPK14CYP3A4EGFR | |
| SCHEMBL5769201 | 0.82 | MAPK14 (0.61) | MAPK14CYP3A4EGFR | |
| SCHEMBL5772550 | 0.81 | MAPK14 (0.59) | MAPK14CYP3A4EGFR | |
| SCHEMBL5772677 | 0.80 | MAPK14 (0.83) | MAPK14CYP3A4EGFR | |
| SCHEMBL5770726 | 0.80 | MAPK14 (0.58) | MAPK14CYP3A4EGFR | |
| SCHEMBL5772519 | 0.79 | MAPK14 (0.70) | MAPK14CYP3A4EGFR | |
| SCHEMBL5774715 | 0.79 | MAPK14 (0.59) | MAPK14CYP3A4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |