Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.80 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.80 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.80 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.80 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.80 |
| ▸ | KDR | P35968 | 3/20 | 0.80 |
| ▸ | FYN | P06241 | 2/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.80 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.80 |
| ▸ | PRKACA | P17612 | 1/20 | 0.80 |
| ▸ | PRKACG | P22612 | 1/20 | 0.80 |
| ▸ | PRKACB | P22694 | 1/20 | 0.80 |
| ▸ | CSF1R | P07333 | 4/20 | 0.55 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5830498 | 1.00 | EGFR (0.80) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5770070 | 1.00 | EGFR (0.80) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5830777 | 0.96 | EGFR (0.87) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5830774 | 0.96 | EGFR (0.87) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5830349 | 0.91 | EGFR (0.83) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5830353 | 0.91 | EGFR (0.83) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5808497 | 0.91 | EGFR (0.82) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5830423 | 0.90 | EGFR (0.72) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5830419 | 0.90 | EGFR (0.72) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL5809941 | 0.89 | EGFR (1.00) | EGFRFGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615928-A1 | PYRIMIDO COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089955-A1 | PYRIMIDO COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-10-21 | — | — | WO | disclosed |