Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853457 | 0.95 | IGF1R (0.53) | IGF1RPIK3C3NEK1 | |
| SCHEMBL2319952 | 0.91 | PIK3C3 (0.55) | IGF1RPIK3C3NEK1 | |
| SCHEMBL5816922 | 0.89 | PIK3C3 (0.54) | IGF1RPIK3C3NEK1 | |
| SCHEMBL29539700 | 0.85 | PIK3C3 (0.50) | IGF1RPIK3C3NEK1 | |
| SCHEMBL22917390 | 0.85 | PIK3C3 (0.50) | IGF1RPIK3C3NEK1 | |
| SCHEMBL5823478 | 0.83 | AURKA (0.40) | IGF1RPIK3C3 | |
| SCHEMBL5819731 | 0.81 | IGF1R (0.48) | IGF1RPIK3C3 | |
| SCHEMBL2321718 | 0.80 | IGF1R (0.68) | IGF1R | |
| SCHEMBL22535344 | 0.77 | PIK3C3 (0.53) | IGF1RPIK3C3NEK1 | |
| SCHEMBL3854177 | 0.77 | IGF1R (0.52) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678169-A1 | 4-(PYRAZOL-3-YLAMINO)PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040159-A1 | 4-(PYRAZOL-3-YLAMINO) PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2005-05-06 | — | — | WO | disclosed |