⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564312 | 0.93 | — | — | |
| Hydrogen Sulfide SCHEMBL7784683 | 0.68 | — | — | |
| Nitrous Acid SCHEMBL7029964 | 0.57 | — | — | |
| Nitrous Acid SCHEMBL21951221 | 0.57 | — | — | |
| SCHEMBL325170 | 0.57 | — | — | |
| Hydrogen Sulfide SCHEMBL5696142 | 0.54 | — | — | |
| Hydrogen Sulfide SCHEMBL1325068 | 0.54 | — | — | |
| Nitrous Acid SCHEMBL11682170 | 0.54 | — | — | |
| Hydrogen Sulfide SCHEMBL11276256 | 0.54 | — | — | |
| SCHEMBL28276641 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349836-B1 | TETRACYCLIC DERIVATIVES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2006-06-14 | — | — | EP | claimed |
| US-6992100-B2 | sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2006-01-31 | — | — | US | claimed |
| US-6974831-B2 | sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-12-13 | — | — | US | claimed |
| US-6930123-B2 | sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-08-16 | — | — | US | claimed |
| US-6916840-B2 | Spla2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-07-12 | — | — | US | claimed |
| US-6872743-B2 | sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-03-29 | — | — | US | claimed |
| EP-1144305-A4 | NOVEL sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2004-11-10 | — | — | EP | claimed |
| US-20040092543-A1 | Novel spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-05-13 | — | — | US | claimed |
| US-20040077704-A1 | Novel spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-04-22 | — | — | US | claimed |
| US-20040063967-A1 | Novel spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-04-01 | — | — | US | claimed |
| EP-1349836-A2 | TETRACYCLIC DERIVATIVES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-10-08 | — | — | EP | claimed |
| EP-1345898-A2 | TERACYCLIC CARBAZOLE DERIVATES AND THEIR USE AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-09-24 | — | — | EP | claimed |
| WO-2002057231-A2 | BENZ(G) INDOLES AND THEIR USE AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-07-25 | — | — | WO | claimed |
| WO-2002050034-A2 | TETRACYCLIC CARBAZOLE DERIVATES AND THEIR USE AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | claimed |
| WO-2002050030-A2 | CYCLOALKYLFUSED [G]-INDOLE COMPOUNDS AS SPLA2-INHIBITORS IN THE TREATMENT OF INFLAMMATORY DISEASES | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | claimed |
| WO-2002050028-A2 | SUBSTITUTED BENZOINDOLES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | claimed |
| WO-2002050029-A2 | TETRACYCLIC DERIVATIVES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | claimed |
| US-6391908-B1 | ANTIINFLAMMATORY AGENTS; THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2002-05-21 | — | — | US | claimed |
| EP-1144305-A1 | NOVEL sPLA 2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-10-17 | — | — | EP | claimed |
| WO-2000037358-A1 | NOVEL sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-06-29 | — | — | WO | claimed |