Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.65 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1748912 | 0.92 | IGF1R (0.56) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL27687967 | 0.92 | IGF1R (0.66) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL27688138 | 0.92 | IGF1R (0.68) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL1748978 | 0.90 | IGF1R (0.74) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL27687982 | 0.85 | IGF1R (0.66) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL27687974 | 0.84 | IGF1R (0.74) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL1749243 | 0.84 | IGF1R (0.74) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL1748850 | 0.82 | IGF1R (0.71) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL1748652 | 0.82 | IGF1R (0.71) | IGF1RSYKRIPK1CDK1CCNB1 | |
| SCHEMBL27688037 | 0.82 | IGF1R (0.73) | IGF1RSYKRIPK1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732546-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095399-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |