Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770065 | 0.89 | MAPK14 (1.00) | MAPK14CYP3A4ABL1EGFRERBB2 | |
| SCHEMBL5769824 | 0.88 | MAPK14 (0.75) | MAPK14CYP3A4ABL1EGFRERBB2 | |
| SCHEMBL5770442 | 0.86 | MAPK14 (0.73) | MAPK14CYP3A4ABL1EGFRERBB2 | |
| SCHEMBL5771722 | 0.85 | MAPK14 (0.70) | MAPK14CYP3A4ABL1EGFRERBB2 | |
| SCHEMBL5771288 | 0.84 | MAPK14 (0.69) | MAPK14CYP3A4ABL1EGFRERBB2 | |
| SCHEMBL5771291 | 0.84 | MAPK14 (0.69) | MAPK14CYP3A4ABL1EGFRERBB2 | |
| SCHEMBL5772677 | 0.82 | MAPK14 (0.83) | MAPK14CYP3A4ABL1EGFRERBB2 | |
| SCHEMBL18041883 | 0.81 | MAPK14 (0.81) | MAPK14CYP3A4 | |
| SCHEMBL5771899 | 0.80 | MAPK14 (0.81) | MAPK14CYP3A4ABL1EGFRERBB2 | |
| SCHEMBL5772247 | 0.79 | MAPK14 (1.00) | MAPK14CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |