Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 11/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.63 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773714 | 0.93 | MAPK13 (0.64) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| SCHEMBL5769686 | 0.92 | MAPK14 (0.61) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5770934 | 0.91 | MAPK13 (0.63) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| SCHEMBL5767767 | 0.91 | MAPK13 (0.63) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| SCHEMBL5768553 | 0.91 | MAPK14 (0.65) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| SCHEMBL5769444 | 0.90 | MAPK13 (0.77) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| Benzamide SCHEMBL28776537 | 0.89 | MAPK14 (0.59) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5771015 | 0.89 | MAPK14 (0.64) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5767317 | 0.89 | MAPK13 (0.56) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| SCHEMBL5769640 | 0.89 | MAPK13 (0.63) | MAPK13MAPK12MAPK11MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100443481-C | Imidazolyl-cyclic acetals | RHONE POULENC RORER LTD (GB) | 2008-12-17 | — | — | CN | disclosed |
| EP-0988301-B1 | IMIDAZOLYL-CYCLIC ACETALS | AVENTIS PHARMA LTD (GB) | 2006-08-09 | — | — | EP | disclosed |
| US-6989395-B2 | Imidazolyl-cyclic acetals | AVENTIS PHARMA LIMITED (GB) | 2006-01-24 | — | — | US | disclosed |
| US-6602877-B1 | Imidazolyl-cyclic acetals | AVENTIS PHARMA LIMITED (GB) | 2003-08-05 | — | — | US | disclosed |