Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769844 | 0.97 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5771853 | 0.92 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5772412 | 0.92 | MAPK13 (0.77) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5773837 | 0.90 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5768890 | 0.90 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5769008 | 0.90 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5768364 | 0.90 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5769067 | 0.90 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5771569 | 0.89 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5769459 | 0.89 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988301-B1 | IMIDAZOLYL-CYCLIC ACETALS | AVENTIS PHARMA LTD (GB) | 2006-08-09 | — | — | EP | disclosed |
| US-6989395-B2 | Imidazolyl-cyclic acetals | AVENTIS PHARMA LIMITED (GB) | 2006-01-24 | — | — | US | disclosed |
| US-6602877-B1 | Imidazolyl-cyclic acetals | AVENTIS PHARMA LIMITED (GB) | 2003-08-05 | — | — | US | disclosed |
| EP-0988301-A1 | IMIDAZOLYL-CYCLIC ACETALS | RHONE-POULENC RORER LIMITED (GB) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998056788-A1 | IMIDAZOLYL-CYCLIC ACETALS | RHONE-POULENC RORER LIMITED (GB) | 1998-12-17 | — | — | WO | disclosed |